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PO.4.87 Racial discrimination and telomere shortening: findings from the black women’s experiences living with lupus (BeWELL) study
  1. DH Chae1,
  2. CD Martz1,
  3. KW Chung1,
  4. DJ Cunningham1,
  5. AM Allen2,
  6. TA Laveist1,
  7. KG Saag3 and
  8. MI Danila3
  1. 1Tulane School of Public Health and Tropical Medicine ~ New Orleans, Louisiana ~ USA
  2. 2University of California, Berkeley, School of Public Health ~ Berkeley, California ~ USA
  3. 3University of Alabama at Birmingham, Heersink School of Medicine ~ Birmingham, Alabama ~ USA


Purpose Black women have the highest prevalence of systemic lupus erythematosus (SLE) in the U.S., and also experience greater severity and worse disease outcomes compared to their white counterparts. Racial discrimination may contribute to more aggressive SLE progression among Black women through physiologic channels engaged by the stress response, resulting in faster telomeric aging as indexed by the rate of leukocyte telomere length (LTL) shortening. Using longitudinal data, this study examined if racial discrimination is associated with LTL among Black women with SLE.

Methods Data were from the Black Women’s Experiences Living with Lupus (BeWELL) Study, a prospective cohort study of 438 Black women, all with a validated diagnosis of SLE and living in metropolitan Atlanta, Georgia. Participants were recruited from April 2015 to May 2017. Linear regression was used to examine LTL assayed from dried blood spots collected at year 1 follow-up, measured as the relative telomere to single copy gene (T/S) ratio. Incident experiences of racial discrimination between baseline and year 1 follow-up were captured in surveys administered at 6-month and year 1 follow-up. Participants were asked how often they had experienced racial discrimination in the past 6 months in the following settings: at school; getting a job; at work; getting housing; medical care; service at a store or restaurant; obtaining credit or a loan; on the street or in a public setting; and from the police or in the courts. Models adjusted for baseline LTL, baseline lifetime racial discrimination, age, years of diagnosis, socioeconomic factors, and other health-related characteristics. Participants who died between baseline and year 1 follow-up (n=9), were missing data on LTL (n=18), and additionally were missing data on any other study variable (n=36) were excluded from analyses, resulting in a total analytic sample size of 375.

Results Examining the interaction between incident racial discrimination and age showed that compared to those reporting no new experiences of racial discrimination in the past year, the negative relationship between age and year 1 LTL was steeper among those reporting high incident racial discrimination (b=-.04, SE=.02, p=.03). The LTL shortening by age was faster among those experiencing high vs. no new experiences of racial discrimination. High racial discrimination was associated with faster LTL shortening particularly among older participants.

Conclusions Racial discrimination has been shown to be a health risk factor among Black Americans, including among Black women living with SLE. Our findings suggest that one mechanism through which racial discrimination may become biologically embedded in this population is via its impact on the telomere maintenance system. This study further demonstrates the need for anti-discrimination policies and practices—for example, in medical care as well as in other societal domains—to address racial inequities in health.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

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